Objective: To investigate the relationship between Frank's sign (FS), a diagonal fold of the earlobe, and the severity of erectile dysfunction (ED), focusing on FS as a potential prognostic marker for ED, particularly its vascular components.

Materials and Methods: A prospective study was conducted on 114 male patients aged 18-80 years at the Andrology Clinic of Haydarpaşa Numune SUAM. Participants were stratified according to International Index of Erectile Function-5 (IIEF-5) scores. FS presence, body mass index (BMI), lipid profiles and inflammatory markers (NLR, PLR) were recorded. Statistical analyses assessed the association between FS, ED severity and cardiovascular risk factors.

Results: A significant correlation was found between FS and ED severity, especially for bilateral FS (p=0.000). Patients with FS had higher BMI and LDL levels, indicating a strong association with cardiovascular risk factors. Atherogenic index and PLR were also significantly associated with ED (p=0.018, p=0.003).

Conclusion: FS, especially bilateral FS, is closely associated with ED severity and its vascular pathology, suggesting its potential use as a prognostic marker in the evaluation of ED. Further research is needed to confirm these findings and to explore the integration of FS into clinical practice.

Keywords : Frank's sign, erectile dysfunction, cardiovascular risk factors