Materials and Methods: In this observational cross-sectional study, YouTube searches were conducted between January 1 and 15, 2026, using Turkish ("Peyronie hastalığı", "penis eğriliği") and English ("Peyronie"s disease", "penile curvature") keywords. After applying inclusion and exclusion criteria, a total of 351 videos (143 Turkish, 208 English) were included. Videos were analyzed according to source of upload, content theme, and engagement metrics. Video quality and reliability were assessed using the JAMA Benchmark Criteria, Modified DISCERN, and Global Quality Score (GQS). Statistical analyses were performed using SPSS version 26.0.

Results: English videos had significantly longer durations and higher view and like counts compared to Turkish videos (all p<0.001). English videos also demonstrated significantly higher JAMA, Modified DISCERN, and GQS scores (p<0.001). Guideline-discordant or incomplete information was identified in 23.8% (34/143) of Turkish videos and 6.7% (14/208) of English videos, with a statistically significant difference between languages (χ²=19.44; p<0.001). Most videos containing guideline-discordant information were uploaded by private practice or private hospital physicians. In both languages, videos focusing on non-surgical treatments exhibited the lowest quality and reliability scores.

Conclusion: English YouTube videos on Peyronie"s disease provide higher-quality and more reliable information compared to Turkish videos. In Turkish content, guideline-discordant information is predominantly concentrated in individually produced and promotional videos. Greater involvement of academic institutions and professional associations in digital health content creation is essential to improve the quality of online patient education.