Grand Journal of Urology
E-ISSN : 2757-7163

Comparison of Pre-COVID-19, COVID-19, and Post-COVID-19 Urinalysis Parameters and Assessment of Their Relationships with Renal Functions
Leyla Ozturk Sonmez1, Hulya Vatansev2, Gokhan Ecer3, Mehmet Giray Sonmez4
1Department of Emergency Medicine, University of Health Sciences, Beyhekim Training and Research Hospital, Konya, Türkiye
2Department of Chest Diseases, Necmettin Erbakan University Meram School of Medicine, Konya, Türkiye
3Department of Urology, University of Health Sciences, Konya Training and Research Hospital, Konya, Türkiye
4Department of Urology, Necmettin Erbakan University Meram School of Medicine, Konya, Türkiye
DOI : 10.5505/GJU.2023.50470
Pages : 054-059
Objective: This study compared the pre-COVID-19, COVID-19, and post-COVID-19 periods of the patients in terms of urinalysis parameters and assessed the relationships between the changes in these parameters and renal functions.

Materials and Methods: Four-hundred-eighty-two moderate and severe COVID-19 patients who had the data of urinalysis performed in the pre-COVID-19 period at most three months before the onset of COVID-19 diagnosis, during COVID-19 disease, and 15 days after they completely recovered from the COVID-19 disease were included in the study. Parameters of bilirubin, erythrocyte, leukocyte, protein, glucose, acidity (pH), and density were analyzed in urine samples, and the results were recorded.

Results: CRP, e-GFR, fibrinogen and D-dimer values were found to be significantly different between the three groups (for all parameters p<0.05). A negative correlation was found between e-GFR and both CRP (p<0.001, r:-0.289) and D-dimer (p:0.02, r:-0.129) values of the patients during COVID-19. Urine pH, presence of leukocyturia, presence of microscopic hematuria and presence of proteinuria were found to be significantly different between the three groups (for all parameters p<0.05). It was determined that these four parameters increased significantly during the COVID-19 period and decreased in the post-COVID-19 period. A negative correlation between urine density and e-GFR (p:0.04, r:-0.175) and a positive (p:0.02, r:0.195) correlation between urine density and CRP were detected during COVID-19.

Conclusion: The significant presence of hematuria and proteinuria during COVID-19 disease in line with the literature data supports the opinion that the disease causes renal involvement. The tendency of the parameters on the post-COVID 15th day to return to normal ranges shows that the effects of the inflammation are reversible after the patients recover from the disease.

Keywords : COVID-19, e-GFR, hematuria, proteinuria, urinalysis
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