Amyloidosis is related to the extracellular deposition of abnormal protein fibrils in various tissues. It is clinically interesting that such cases" clinical, radiological, and even endoscopic presentation mimic urothelial carcinoma to a great extent. Here, we discuss a case of a 34-year-old gentleman who presented with frank painless hematuria. The patient was diagnosed with a bladder mass suspicious of malignancy depending on the clinical presentation aided by the cystoscopic and radiological evaluation. Histopathologic samples of the transurethral resection of the mass proved to be primary bladder amyloidosis. Further investigations of systemic illness excluded the secondary amyloidosis. The purpose of this case presentation is to create awareness among the urologists to think for the rare entity of urinary amyloidosis especially if the histopathology is negative for the malignant cells.

Keywords : amyloidosis, TUR, malignancy, Congo red