Evaluation of Risk Factors in Children with Hypospadias

Eda Celebi Bitkin

doi:10.5222/GJU.2021.47956

Eda Celebi Bitkin¹, Alper Bitkin², Ender Cem Bulut², Oguz Tuncer³

¹Department of Pediatrics, Division of Pediatric Endocrinology, Van Yuzuncu Yil University Faculty of Medicine, Van, Turkey
²Department of Urology, University of Health Sciences, Van Training and Research Hospital, Van, Turkey
³Department of Pediatrics, Van Yuzuncu Yil University Faculty of Medicine, Van, Turkey

DOI : 10.5222/GJU.2021.47956

Pages : 62-65

Objective: Hypospadias is one of the most common congenital defects in boys. Multifactorial factors such as genetic predisposition and environmental factors play a role in the etiology of hypospadias. In this study, we investigated the risk factors of patients diagnosed with hypospadias.

Materials and Methods: Thirty-six patients who applied to the pediatric endocrinology and urology outpatient clinics with the diagnosis of hypospadias were evaluated retrospectively. Risk factors were evaluated by recording the parental ages, exposure to environmental factors, the maternal BMI, history of pregnancy, drug use, and the father's fertility status.

Results: The mean age of the patients was 3.5 ± 2 years. The patients had anterior (n:27 : 75%), middle (midshaft) (n:8 ; 22.2%), and posterior (n:1 ; 2.8%) hypospadias. The mean body mass index (BMI) of the mothers was 24 ± 4.1 kg/m2. Eight (22.2%) mothers were overweight and six (16.6%) mothers were obese. There was a history of hypospadias in the family of 4 (11%) patients.

Conclusion: Although combinations of environmental and genetic factors play a role in the etiology of hypospadias, many unexplained factors are responsible for this disease.

Keywords : hypospadias, risk factors, etiology, family history

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Evaluation of Risk Factors in Children with Hypospadias by Eda Celebi Bitkin is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.