Grand Journal of Urology
E-ISSN : 2757-7163

Correlation of Periprostatic Fat Thickness Measured on Multiparametric MRI with Prostate Cancer Aggressiveness
Dogukan Sokmen1, Bedriye Koyuncu Sokmen2
1Department of Urology, Androexpertise Men’s Health and Aesthetics Center, Istanbul, Türkiye
2Department of Radiology, Acıbadem Atakent Hospital, Istanbul, Türkiye
DOI : 10.5505/GJU.2022.03522
Pages : 008-013
Objective : In this study, the relationship between periprostatic and subcutaneous fat thickness on MRI (magnetic resonans imaging) and Gleason scores (GS) was retrospectively evaluated.

Materials and Methods: Fifty-one patients who underwent MRI before application of MRI fusion biyopsies were included 63,57±8,5 (45-88) years) in this study, On midsagittal T2- weighted MR images, the thickness of subcutaneous and periprostatic fat was calculated as the vertical distance from the pubic symphysis both to the skin and to the prostate, respectively.

Results: The mean (±SD) subcutaneous fat thickness (SCFT) and periprostatic fat thickness (PPFT) were 17.38±13.02 mm and 5.64±3.89 mm, respectively. A positive correlation was found between Gleason scores and PPFT (p<0.001), SCFT (p<0.001), body mass indices (BMIs) (p<0.001), prostate spesific antigen values (PSA) (p=0.002), PSA density (p<0.001). In multivariate analysis, only PPFT was found to be statistically significant in predicting GS ≥7 (p=0.005). It has been shown that the risk of detecting GS ≥7 prostate cancer increases 8.9 times with one mm increase in PPFT values.

Conclusion: Periprostatic fat tissue thickness can be used as an independent predictive factor in foreseeing prostate cancer aggressiveness before application of biopsy or radical prostatectomy.

Keywords : Magnetic resonance imaging, periprostatic fat thickness, prostate cancer, Gleason score
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