Grand Journal of Urology
E-ISSN : 2757-7163

Current Issue
Dear colleagues, I am honored to share with you the third issue of 2022 of the Grand Journal of Urology (Grand J Urol) with the contributions of many respected researchers and authors. Our journal has been abstracted/indexed in EBSCOhost, J-Gate, Index Copernicus International (World of Journals List), EuroPub, SciLit, ResearchGate, ScienceGate and Google Scholar international databases. As of these achievements, the Grand Journal of Urology (GJU) has taken its place among the journals indexed by international databases. Grand Journal of Urology (GJU) aims to carry written and visual scientific urology studies to academic platforms and to make significant contributions to the science of urology. In this issue of our journal, there are many valuable articles under the subheadings of Andrology, General Urology, Laparoscopic and Robotic Surgery, Female Urology, and Urological Oncology. I hope that these carefully prepared articles will make important contributions to valuable readers, researchers and the urology literature. On this occasion, I would like to express my heartfelt gratitude to our authors who have contributed to our journal with their articles, to our reviewers who have meticulously evaluate the articles. Respectfully yours September 2022 Assoc. Prof. Ekrem GUNER, MD Editor-in-Chief
Original Article
General Urology, Online First: 27 June 2022
Grand J Urol 2022;2(3):087-092, DOI: 10.5505/GJU.2022.32032
Objective: We aimed to analyze and report the outcomes of patients with retroperitoneal bleeding (RPB) among our COVID-19 inpatients under anticoagulation therapy. Materials and Methods: We retrospectively analyzed 54 patients who were anticoagulated with low- molecular-weight heparin (LMWH) and developed RPB during COVID-19 treatment in the hospital, either in intensive care unit or non-intensive care unit services, between March 2020 and March 2021. The patients' demographic and clinical data were analyzed, and we compared the laboratory results at the time of admission and during episodes of RPB. The patients were divided into conservative and interventional treatment groups. We compared the size of retroperitoneal hematoma, anticoagulant doses, erythrocyte suspension transfusion rates, presence of hyperinflammation syndrome between these groups. Also, treatment modalities and mortality status were shown. The hematoma size and erythrocyte suspension transfusion rates were compared between groups, and their correlation with anticoagulant dose and age were analyzed as well. Results: In the management of RPB that developed, 48 (88.9%) patients were approached conservatively, 4 (7.4%) patients underwent angioembolization, and 2 (3.7%) patients laparotomy. Mortality was observed in 14 (25.9%) patients. Relevant laboratory parameters as lactate dehydrogenase, procalcitonin, interleukin-6 levels and lymphocyte counts were elevated exceedingly, while the hemogram test values were significantly lower during episodes of RPB (p=0.007, p=0.044, p=0.031, p=0.018 and p
Laparoscopic and Robotic Surgery, Online First: 05 August 2022
Grand J Urol 2022;2(3):093-099, DOI: 10.5505/GJU.2022.52724
Objective: To compare the open simple prostatectomy (OSP) and laparoscopic simple prostatectomy (LSP) performed due to benign prostatic enlargement greater than 80 cc. Materials and Methods: Between January 2015 and July 2021, patients who underwent OSP and LSP were retrospectively screened. The patients" demographic, preoperative, perioperative, and postoperative data were noted and compared. Results: The data of a total of 90 patients, including 55 (61.1%) cases in the OSP and 35 cases (38.9%) in the LSP group were analyzed. Age, comorbidity rates, and body mass index scores of the patients were comparable. There was also no significant difference in the preoperatively calculated mean prostate volume, and Qmax of the cases. The mean operative time was significantly longer for LSP (p
Objective: The primary aim of this study is the determination of International Society of Urological Pathology (ISUP) grade group (GG) upgrading prevalence and its risk factors in prostate cancer patients. Materials and Methods: This study was conducted on 117 patients who all underwent open radical prostatectomy in our institution between 2011 and 2020. Patients who received neoadjuvant therapy prior to surgery and had metastasis in lymph nodes or bones were excluded from the study. Results: In 28 (23.9%) cases ISUP GG had upgraded in final pathology. While grade group of 81 (69.2%) patients did not change, it was downgraded in the remaining 8 (6.8%) cases. In the univariate analysis for the predictors of ISUP GG upgrade, ISUP GG distribution in biopsy pathology (OR: 0.46, 95% CI: 0.26-0.82, p=0.009), positive core fraction (PCF) (OR: 0.07, 95% CI 0.01-0.85, p=0.037), greatest positive core percentage (GPC) (OR: 0.12, 95% CI: 0.02- 0.68, p=0.016) and extraprostatic invasion extended (EPI-extended) (OR: 2.95, 95% CI: 1.16- 7.49, p=0.023) were all identified as significant factors. When these significant factors were analyzed in multivariate logistic regression analysis, biopsy ISUP grade (OR: 0.38, 95% CI: 0.18-0.79, p=0.01), greatest percentage of cancer (GPC) (OR: 0.10, 95% CI 0.01-0.78, p=0.027) and EPI-extended (OR 14.9, 95% CI:3.1-71.9, p=0.01) were shown as independent predictors. Conclusion: ISUP GGs of a significant number of patients upgrade in the final pathology. Initial biopsy ISUP score and greatest positive core percentage in the biopsy are independent predictors of ISUP GG upgrade risk. EPI-extended was also significantly higher in ISUP upgrade group. Tumor upgrade risk should be considered prior to prostate cancer treatment.
Female Urology, Online First: 10 September 2022
Grand J Urol 2022;2(3):108-113, DOI: 10.5505/GJU.2022.99608
Objective: This study aims to evaluate the frequency of hydronephrosis and the effect of hydronephrosis on urodynamic parameters in patients with advanced-stage pelvic organ prolapse (POP). Materials and Methods: This retrospective cross-sectional study was conducted between July 2019 - February 2020 with 66 patients who were admitted to the urogynecology outpatient clinic with symptomatic advanced-stage POP. Urinary system ultrasonography and urodynamic examination were performed on all patients before the operation. The severity of prolapse in the study population was evaluated using the POP-Q system. Urinary system ultrasonography was performed by radiologists. Demographic data, POP time, and urodynamic parameters were compared in hydronephrosis and non-hydronephrosis cases. Results: The general frequency of hydronephrosis among the patients was 19.7% (13/66 patients). It was found that the weight (p= 0.0001) and body mass index (p= 0.004) levels were higher in patients with hydronephrosis. There was no significant difference in the duration of POP, the presence of detrusor overactivity, and other urodynamic parameters in patients with or without hydronephrosis. Conclusion: There was no relationship found between hydronephrosis and urodynamic parameters. In line with these data, urinary system ultrasonography is recommended for all patients with POP due to the high frequency of hydronephrosis and the consequences of hydronephrosis leading to renal failure.
Case Report
Andrology (Male Sexual Disfunction, Infertility), Online First: 30 June 2022
Grand J Urol 2022;2(3):114-116, DOI: 10.5505/GJU.2022.02996
In the evaluation of a 32-year-old male patient who was referred to our clinic with the complaint of gynecomastia and primary infertility, ennuchoid structure, hypergonadotropic hypogonadism, and azoospermia were detected. Based on these findings, the genetic evaluation revealed the presence of 48XXYY syndrome. In this case report, we aimed to report the diagnostic algorithm and management of 48 XXYY syndrome. It should be noted that fertility should not be expected in patients with 48XXYY syndrome.
Urological Oncology, Online First: 27 August 2022
Grand J Urol 2022;2(3):117-121, DOI: 10.5505/GJU.2022.58068
Paratesticular liposarcomas (PLSs) are mostly painless, slow-growing and extremely rare inguinal or scrotal masses. Reports of approximately 270 cases have been published in the literature so far, but only a few of them contain information about giant PLSs exceeding 10 cm in size. Correct diagnosis and treatment is important as PLSs tend to cause local relapses and distant metastases. Here, we aimed to present, and evaluate a dedifferentiated (24 cm), and a well-differentiated (12 cm) giant PLS in the light of the literature data.
General Urology, Online First: 31 August 2022
Grand J Urol 2022;2(3):122-125, DOI: 10.5505/GJU.2022.72692
Zinner syndrome is a rarely seen congenital anomaly characterized with developmental defects of mesonephric (Wolffian) duct including obstruction of the ejaculatory duct, an ipsilateral seminal vesicle cyst, and an ipsilateral renal agenesis. Patients may present with genitourinary system complaints, or they may be completely asymptomatic and detected incidentally. Minimally invasive cyst aspiration and surgical treatment are mainly aimed for symptomatic relief. In this article, a rare case of Zinner Syndrome presenting with signs of urinary retention is presented.
Letter to the Editor
Andrology (Male Sexual Disfunction, Infertility), Online First: 04 July 2022
Grand J Urol 2022;2(3):126-127, DOI: 10.5505/GJU.2022.58076
Dear editor, We have read with great interest, the case series and literature review of false penile fracture by Ozlu et al. in which the authors share clinical experience with more than 100 patients over a 13-year period []. By examination of operative reports, they retrospectively evaluated the patients with a pre-diagnosis of penile fracture and frankly reported a misdiagnosis rate of approximately 8%. This ratio is comparable and consistent with the literature [-]. Examining the patient clinical and operative characteristics, shown as a table on a separate page, we see that only two of total eight false penile fracture cases underwent radiological examination. Magnetic resonance imaging (MRI) was preferred in these patients, and it was stated that one of them was MRI positive (patient 4) and the other was MRI false positive (patient 2). Patients with a tunical tear in preoperative MRI, but no tear in surgical exploration were considered to have false penile fracture. Since only ligation procedures were performed on both MRI positive and MRI false positive patients, we think that such a distinction is confusing and not necessary. Perhaps ultrasonography could be preferred for the remaining six patients for whom radiological examination was not performed, due to its easy accessibility and provide medical recording. However, an ideal radiographic imaging modality is still lacking so far []. Although there are some clinical differences between false and true penile fractures, the two conditions cannot be clearly distinguished from each other either clinically or radiologically []. Consequently, we would like to encourage Ozlu et al., on a very diligently written and quite informative article that briefly summarizes the studies that have already been published and the approach to the patient with penile fracture. Urologists somehow have to base the definitive diagnosis of penile fracture on surgical exploration in order to eliminate serious long-term potential problems of an overlooked tunical tear. Sincerely yours. Ethics Committee Approval: This article does not contain any studies with human participants performed by the author. Authorship Contributions: Any contribution was not made by any individual not listed as an author. Concept - B.K.A., O.L.O.; Design - B.K.A., O.L.O.; Supervision - B.K.A., O.L.O.; Resources - B.K.A., O.L.O.; Materials - B.K.A., O.L.O.; Data Collection and/or Processing - B.K.A., O.L.O.; Analysis and/ or Interpretation - B.K.A., O.L.O.; Literature Search - B.K.A., O.L.O.; Writing - B.K.A., O.L.O.; Critical Review - B.K.A., O.L.O. Conflict of Interest: The author declares that he has no conflict of interest. Financial Disclosure: No grants or funding was provided for this study.